M8-B Hydrochloride( —— )

Catalog No. M21971 CAS No. 883976-12-3

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

M8-B Hydrochloride
Note

Research use only, not for human use.
Brief Description

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist.
Description

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.
In Vitro

——
In Vivo

Animal Model:Trpm8+/+ rats and mice Dosage:6 mg/kg Administration:I.v. or i.p.Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRPM8
Research Area

——
Indication

——

Chemical Information

CAS Number

883976-12-3
Formula Weight

432.96
Molecular Formula

C22H25ClN2O3S?
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (577.42 mM)
SMILES

Cl.COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Zandi N , Zaniani N R , Moghimi A , et al. Protective effects of M8?B, a TRPM8 antagonist, on febrile? and pentylenetetrazol?induced seizures[J]. Acta neurobiologiae experimentalis, 2019, 79(1):86-91. 2. Almeida M C , Hew-Butler T , Soriano R N , et al. Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature[J]. Journal of Neuroscience, 2012, 32(6):2086-2099.

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M8-B Hydrochloride( —— )

Catalog No. M21971 CAS No. 883976-12-3